Research
Cellular Protein Expression
Differential Protein Expression
Protein Expression Profiles
Experimental Cellular Physiology
Carbon Nanotubes, Carbon Nanotube
Autosomal Recessive Polycystic Kidney Disease
Low Levels, Low Level
Cyst Growth
Parental Cell Line
Multiple Cellular Functions
Blood Pressure
Barrier Function
Dose Groups
Relative Expression
High Doses, High Dose
Vitro Model
Unique Proteins
Bioinformatic Analysis
Digestive Tract
Biomedical Nanoscience
Bile Ducts
Concentrations Substantially Lower
Nanoparticle Exposure
Log Unit Range
Three Different Times
Inflammatory Response, Inflammatory Responses
Electrophysiological Measurements
Oxidative Stress, Oxidant Stress
Physiologically Relevant Concentrations
Physiologically Relevant Exposures
Potential Alterations
High Concentrations, High Concentration
Chronic Exposure, Chronic Exposures
Functional Changes
Kidney Tubules
Cultured Renal Cells
Volume Retention
Peroxisome Proliferator
Receptor Gamma
Channel Activation, Channel Activity
Electrophysiological Methods
Normal Serum
Low Concentrations, Low Concentration
Late Stage Disease
Inverse Correlation
Slow Growth
Food Chain
Renal Function
Multiple Fluid
Cytokine Release
Renal Injury
Lactate Dehydrogenase
Environmental Pollution
Barrier Cell Function
Ion Transporter Function
Current Study, Current Studies
Drug Induced Changes
Cystic Burden
Alternative Pathways
Human Studies
Current Understanding
Genetic Disorders, Genetic Disorder
Known Physiological Principles
Organ Transplantation
Negative One
Transport Proteins, Transport Protein
Clinical Management
Drug Treatments, Drug Treatment
Positive Aspect
Potential Mechanism, Potential Mechanisms
Protein Composition
Intracellular Signaling Pathways, Intracellular Signaling Pathway
Fluid Proteome
Plasma Membrane
Insulin Stimulation
High Resistance Clone
Kinase Activity, Kinase Activation
Mouse Model, Mouse Models
Cellular Proliferation
Cyst Formation
Fluid Accumulation
Hormonal Regulation
Lipid Based Signaling Pathway
Dose Response Relationships
Electron Microscopy
Common Genetic Variant
Cellular Level, Cellular Levels
Common Variants, Common Variant
Plasma Volume
Signal Transduction Cascade
Lipid Signal Transduction
Plasma Proteins, Plasma Protein
Four Patients
Complement Component, Complement Components
Glucose Utilization
Complex Collection
Relevant Proteins
Mechanistic Features
Major Role
Insulin Sensitizers, Insulin Sensitivity
Blue Distribution
Diabetes Patients, Diabetic Patient, Diabetic Patients
Recent Observations
Body Weight
Vitamin D Binding Protein
Even Greater Number
Mechanistic Interest
Parent Line
Confocal Microscopy
Live Cell, Living Cells, Live Cells
Water Homeostasis
Mammalian Model System
Urinary Bladder, Urinary Bladders
Mammalian Lines
Underlying Mechanisms, Underlying Mechanism
Hormonal Stimulation
Present Studies, Present Study
Functional Responses
Steroid Hormones, Steroid Hormone
Ion Transport Responses
Principal Cell Type
Phosphoinositide Pathway
Dependent Protein Kinases, Dependent Protein Kinase
Wide Variety
Intracellular Site
Physical Mechanisms
Endogenous Levels
Electrophysiological Analyses
Unique Observation
New Insights, New Insight
Severe Disease, Several Diseases
Renal Salt
Significant Functional Diversity
Substantial Fibrosis
Two Isoforms
Distinct Proteins
Length Analysis
Wild Type Animals
Cardiovascular Diseases, Cardiovascular Disease
Protein Function
Potential Impact, Potential Impacts
Numerous Fluid
Defining Feature, Defining Features
Proteomic Analysis
New Mechanism
Potential Functional Significance
Enhanced Inflammatory Cell Processes
Different Intracellular Locations
Intracellular Transport
Protein Identifications
Functional Variation
American Societies, American Society
Initial Step
Disease Progression
Well Characterized Cell Culture Model
Differential Function
Abnormal Variability
Active Components
Functional Implications
Enriched Proteome
Intracellular Localization
Intracellular Compartment, Intracellular Compartments
Human Polymorphism
Pi Pathway
Tight Junctions, Tight Junction
Short Circuit Current Measurement
Cellular Responses, Cellular Response, Cellular Responsiveness
Channel Regulation, Channel Regulators
Signaling Intermediates
Membrane Targeting
Hormone Responsive Model
Electrophysiological Technique, Electrophysiological Techniques
Insulin Like Growth Factor
Basal Transport
Noise Analysis
Fold Enhancement
New Paradigm, New Paradigms
Pertinent Transport Regulators
Readily Accessible Pool
Low Abundance
Native Cells
Laser Scanning
Important Role, Important Roles
Several Steps
Three Dimensional Space
Regulated Protein
Downstream Element
Real Time
Insulin Signal
Cellular Excess
Three Dimensional Images, Three Dimensional Imaging
Current Model, Current Models
Acute Response
Channel Densities, Channel Density
Specific Inhibitors, Specific Inhibitor
Water Balance
Channel Function
Stream Signaling
Physiological Concentration Ranges
Recent Results
Tested Populations
Latter Forms
Final Delivery
Dynamic Processes, Dynamic Process
Increased Na
Multiple Cellular Events
Notably Pi
Important Results
Selective Agonists
Discrete Membrane Domains
Second Messengers, Second Messenger
Transport Processes, Transport Process
Pharmacologic Agent, Pharmacological Agents
Candidate Mechanism
Mycotoxin Ochratoxin
Physiological Function, Physiological Functions
Acute Exposure
Large Proportion
Various Hormones
Well Characterized Transport Systems
Commercial Animals
Duct Cells
Hormone Efficacy
Indirect Mechanism
Exposed Animals
Multiple Forms
Transporter Kinetics
Recent Studies, Recent Study
Quantitative Pcr Analyses
Electrolyte Transport
Respective Cellular Domain
Membrane Stability
Recently Described
Clinical Studies
Cell Model
Lower Abundance Forms
Electrophysiological Methodologies
Common Contaminant
Dose Response Curves
Electrophysiological Responses
Differential Phosphorylation
Proper Targeting
Cellular Components
Fluid Balance
Possible Role
H Selectively
Relatively Small Initial Increase
Open Probability
Single Channel Current
Baseline Values
Baseline Rates
High Affinity Ligand Binding
Cellular Protein Methylation
Early Time Dependent Stimulation
Distal Sections
Inhibitable Pi
Averaging Near
Completely Reversible Inhibition
Western Blot, Western Blotting, Western Blots
Reversible Increase, Reversible Increases
Transport Rates
Many Characteristics
Binding Site, Binding Sites
Native Principal Cells
Biochemical Pathways
Time Course, Time Courses
Single Channel Conductance
Channel Proteins
Camp Production
Insulin Receptor, Insulin Receptors
One Approach
Specific Cellular Process
Dose Dependent Manner, Dose Dependent Manners
Maximal Responses, Maximal Response
Transport Acting
Transport Pathway
Sodium Channels
Native Tissues
Potential Interactions
Several Hormones
Fold Increase
Previous Reports
Various Regulatory Factors
Entirely Different Mechanisms
Two Hormones
Early Time Dependent Response
Fold Range
New Modified Method
Threefold Differences
Transient Conditions
Three Groups
Highest Rates
Various Time Points
First Demonstration
Biophysical Methods
Previous Study, Previous Studies
Highly Selective Na
High Affinity Binding
Important Channel
Signaling Step
First Committed Step
Elucidating Mechanisms Underlying Regulation
Key Role, Key Roles
Biophysical Approaches
Important Component, Important Components
Subsequent Response
Physiological State
Ideal Model
Additive Mechanisms
Many Hormones
Hormonal Modulation
Conductive Na
Signal Transduction Mechanisms
Classical Model
Sustained Response
Greater Extent
Potential Regulatory Component
Alternate Receptor
Binding Characteristics
Receptor Localization
Intact Tissues
Anti Insulin
Two Models, Two Model
Similar Increases
Cellular Growth
Final Transport
Ligand Receptor Binding
Ligand Receptor Complexes
Concentration Dependent, Concentration Dependence
Antigen Challenge
Food Allergy
Milk Proteins
G Class
Immunologic Basis
Immune Serum
List of Publications (43)
In 2013
43
Protein expression profiles of intestinal epithelial co-cultures: effect of functionalised carbon nanotube exposure.
Found on Publication Page
In 2012
In 2011
41
Effect of carbon nanoparticles on renal epithelial cell structure, barrier function, and protein expression.
Found on Publication Page
40
Lysophosphatidic acid is a modulator of cyst growth in autosomal dominant polycystic kidney disease.
Found on Publication Page
In 2010
In 2009
37
Structural and functional analyses of liver cysts from the BALB/c-cpk mouse model of polycystic kidney disease.
Found on Publication Page
35
A human polymorphism affects NEDD4L subcellular targeting by leading to two isoforms that contain or lack a C2 domain.
Found on Publication Page
34
Protein composition of liver cyst fluid from the BALB/c-cpk/+ mouse model of autosomal recessive polycystic kidney disease.
Found on Publication Page
In 2008
31
Lack of the serum and glucocorticoid-inducible kinase SGK1 attenuates the volume retention after treatment with the PPARgamma agonist pioglitazone.
Found on Publication Page
30
Characterization of the renal cyst fluid proteome in autosomal dominant polycystic kidney disease (ADPKD) patients.
Found on Publication Page
29
Vasopressin regulates the phosphorylation state of AMP-activated protein kinase (AMPK) in MDCK-C7 cells.
Found on Publication Page
In 2006
In 2005
27
Phosphoinositide lipid second messengers: new paradigms for transepithelial signal transduction.
Found on Publication Page
26
Expression of the unconventional myosin Myo1c alters sodium transport in M1 collecting duct cells.
Found on Publication Page
25
Effect of the mycotoxin, ochratoxin A, on hormone-stimulated ion transport in a cultured cell model of the renal principal cell.
Found on Publication Page
24
PPARgamma agonists do not directly enhance basal or insulin-stimulated Na(+) transport via the epithelial Na(+) channel.
Found on Publication Page
In 2004
23
Real-time three-dimensional imaging of lipid signal transduction: apical membrane insertion of epithelial Na(+) channels.
Found on Publication Page
22
The role of the phosphoinositide pathway in hormonal regulation of the epithelial sodium channel.
Found on Publication Page
In 2003
In 2002
20
sgk: an essential convergence point for peptide and steroid hormone regulation of ENaC-mediated Na+ transport.
Found on Publication Page
In 2001
19
Characterization and imaging of A6 epithelial cell clones expressing fluorescently labeled ENaC subunits.
Found on Publication Page
In 2000
18
LY-294002-inhibitable PI 3-kinase and regulation of baseline rates of Na(+) transport in A6 epithelia.
Found on Publication Page
In 1999
In 1998
13
Phosphatidylinositol 3-kinase activation is required for insulin-stimulated sodium transport in A6 cells.
Found on Publication Page
In 1997
In 1996
10
Characterization of hormone-stimulated Na+ transport in a high-resistance clone of the MDCK cell line.
Found on Publication Page
8
Aldosterone and insulin stimulate amiloride-sensitive sodium transport in A6 cells by additive mechanisms.
Found on Publication Page
In 1994
7
Differential effects of brefeldin A on hormonally regulated Na+ transport in a model renal epithelial cell line.
Found on Publication Page
In 1992
6
Aldosterone-mediated Na+ transport in renal epithelia: time-course of induction of a potential regulatory component of the conductive Na+ channel.
Found on Publication Page
4
Insulin and IGF1 receptors in a model renal epithelium: receptor localization and characterization.
Found on Publication Page
In 1989
In 1988
In 1987
1
Affinity purified immunoglobulin G transfers immediate hypersensitivity to guinea pig colonic epithelium in vitro.
Found on Publication Page