Eva Sapi

Profile Picture of Eva Sapi
Title
Associate Professor
Department
Biology & Environmental Science
Institution
University of New Haven
Email
ESapi@newhaven.edu

Education

  • Ph.D. Genetics and Molecular Biology, 1995 Eotvos Lorand University, Budapest, Hungary
  • M.S. Genetics and Molecular Biology, 1987 Eotvos Lorand University, Budapest, Hungary

Research Interests

Lyme Disease   Case Report   Antibiotics Resistance  

  View all research interests

Biography

Eva Sapi Ph.D. is an Associate Professor and University Research Scholar at the Department of Biology and Environmental Science where she teaches undergraduate and graduate biology courses and carries out Lyme disease research with her graduate students. Her research interest is to investigate the different forms of Borrelia burgdorferi for the better understanding how Borrelia can hide from the immune system as well as from antimicrobial therapies. Her recent research shows that Borrelia burgdorferi is capable forming a protective layer around itself ? called biofilm ? which could render it to be very resistant to antibiotics and provide a logical explanation as to why extensive antibiotic treatment for patients with a tick-bite history could fail. The goal of her research group is to fully characterize this novel form and to identify novel antibacterial agents that are effective in killing all forms of Borrelia burgdorferi. Dr. Sapi organized and chaired six Lyme Disease Symposiums at the University of New Haven during the last several years.

Homepages

Contact Information

  203-479-4552

Research
Not mentioned yet. (?)
List of Publications (50)
In 2015
50

Exploring the association between Morgellons disease and Lyme disease: identification of Borrelia burgdorferi in Morgellons disease patients. Marianne J Middelveen, Cheryl Bandoski, Jennie Burke, Eva Sapi, Katherine R Filush, Yean Wang, Agustin Franco, Peter J Mayne, Raphael B Stricker

Found on Publication Page
49

Culture and identification of Borrelia spirochetes in human vaginal and seminal secretions. Marianne J. Middelveen, Jennie Burke, Eva Sapi, Cheryl Bandoski, Katherine R. Filush, Yean Wang, Agustin Franco, Arun Timmaraju, Hilary A. Schlinger, Peter J. Mayne, Raphael B. Stricker

Found on Publication Page
In 2014
48

Filarial Nematode Infection in Ixodes scapularis Ticks Collected from Southern Connecticut. Pabbati Namrata, Jamie Miller, Madari Shilpa, Patlolla Reddy, Cheryl Bandoski, Michael Rossi, Eva Sapi

Found on Publication Page
47

Granulomatous hepatitis associated with chronic Borrelia burgdorferi infection: a case report. Marianne J Middelveen, Steve A McClain, Cheryl Bandoski, Joel R Israel, Jennie Burke, Alan B MacDonald, Arun Timmaraju, Eva Sapi, Yean Wang, Agustin Franco, Peter J Mayne, Raphael B Stricker

Found on Publication Page
In 2013
46

Improved Culture Conditions for the Growth and Detection of Borrelia from Human Serum. Eva Sapi, Namrata Pabbati, Akshita Datar, Ellen M Davies, Amy Rattelle, Bruce A Kuo

Found on Publication Page
45

Association of spirochetal infection with Morgellons disease.. Marianne J Middelveen, Divya Burugu, Akhila Poruri, Jennie Burke, Peter J Mayne, Eva Sapi, Douglas G Kahn, Raphael B Stricker

Found on Publication Page
In 2012
44

Sapi E, Bastian SL, Mpoy CM, Scott S, Rattelle A, Pabbati N, Poruri A, Burugu D, Theophilus PAS, Pham TV, Datar D, Dhaliwal NK, MacDonald A, Rossi MJ, Sinha SK and Luecke DF. Characterization of biofilm formation by Borrelia burgdorferi in vitro. PLoS ONE 2012 October 7(10): e48277.

Found on Publication Text
43

Characterization of Biofilm Formation by Borrelia burgdorferi In Vitro. Eva Sapi, Scott L Bastian, Cedric M Mpoy, Shernea Scott, Amy Rattelle, Namrata Pabbati, Akhila Poruri, Divya Burugu, Priyanka A S Theophilus, Truc V Pham, Akshita Datar, Navroop K Dhaliwal, Alan Macdonald, Michael J Rossi, Saion K Sinha, David F Luecke

Found on Publication Page
In 2011
42

Evaluation of in-vitro antibiotic susceptibility of different morphological forms of Borrelia burgdorferi. Eva Sapi, Navroop Kaur, Samuel Anyanwu, David F Luecke, Akshita Datar, Seema Patel, Michael Rossi, Raphael B Stricker

Found on Publication Page
41

Intermediate Frequency AC Signal Analysis for Bionanosensor. Vishal Desai, Srisowmya Sanisetty, Benjamin Steber, Eva Sapi, Bouzid Aliane, Saion Sinha, Prabir Patra

Found on Publication Page
In 2010
40

Datar, A., Kaur, N., Patel, S., Luecke D.F., and Sapi E. In vitro effectiveness of Samento and Banderol herbal extracts on the different morphological forms of Borrelia burgdorferi.Townsend Letter, 2010 July, 324, 87- 90.

Found on Publication Text
In 2009
39

Sapi, E: Biofilms: A New Hideout for Borrelia burgdorferi? Lyme Times 2009 February p45.

Found on Publication Text
38

Novel cancer stem cell therapy on the horizon. Eva Sapi

Found on Publication Page
In 2008
37

Sapi, E. and MacDonald A. Biofilms of Borrelia burgdoferi in chronic cutaneous borreliosis. 2008 Am J Clin Pathol 129. p.988-989.

Found on Publication Text
In 2005
36

Telomerase prolongs the lifespan of normal human ovarian surface epithelial cells without inducing neoplastic phenotype. Ayesha B Alvero, David A Fishman, Mazin B Qumsiyeh, Manish Garg, Barry M Kacinski, Eva Sapi

Found on Publication Page
In 2004
35

Improved method for the detection of cytokeratin 19-positive cells in the peripheral blood of breast cancer patients. Ayesha B Alvero, Barbara A Burtness, Adife Gulhan Ercan, Eva Sapi

Found on Publication Page
34

A novel immortalized human endometrial stromal cell line with normal progestational response.. Graciela Krikun, Gil Mor, Ayesha Alvero, Seth Guller, Frederick Schatz, Eva Sapi, Mizanur Rahman, Rebeca Caze, Mazin Qumsiyeh, Charles J Lockwood

Found on Publication Page
33

cDNA microarray analysis of invasive and tumorigenic phenotypes in a breast cancer model.. Harriet M Kluger, Yuval Kluger, Maureen Gilmore-Hebert, Kyle DiVito, Joseph T Chang, Sofya Rodov, Olga Mironenko, Barry M Kacinski, Archibald S Perkins, Eva Sapi

Found on Publication Page
32

Resistance of ovarian carcinoma cells to docetaxel is XIAP dependent and reversible by phenoxodiol.. Eva Sapi, Ayesha B Alvero, Wei Chen, David O'Malley, Xiao-Ying Hao, Bambang Dwipoyono, Manish Garg, Marijke Kamsteeg, Thomas Rutherford, Gil Mor

Found on Publication Page
31

The role of CSF-1 in normal physiology of mammary gland and breast cancer: an update.. Eva Sapi

Found on Publication Page
In 2003
30

Phenoxodiol - an isoflavone analog - induces apoptosis in chemoresistant ovarian cancer cells. Marijke Kamsteeg, Thomas Rutherford, Eva Sapi, Bozena Hanczaruk, Shoreh Shahabi, Maryann Flick, David Brown, Gil Mor

Found on Publication Page
29

Interaction of the estrogen receptors with the Fas ligand promoter in human monocytes.. Gil Mor, Eva Sapi, Vikki M Abrahams, Thomas Rutherford, Joon Song, Xiao-Ying Hao, Saeher Muzaffar, Fortune Kohen

Found on Publication Page
In 2002
28

Adenoviral vectors with E1A regulated by tumor-specific promoters are selectively cytolytic for breast cancer and melanoma. Lixin Zhang, Hakan Akbulut, Yucheng Tang, Xueyuan Peng, Giuseppe Pizzorno, Eva Sapi, Sebastian Manegold, Albert Deisseroth

Found on Publication Page
27

Regulation of Fas ligand expression by estrogen in normal ovary. Eva Sapi, Wendi D Brown, Sarit Aschkenazi, Chung Lim, Amanda Munoz, Barry M Kacinski, Thomas Rutherford, Gil Mor

Found on Publication Page
26

Detection of telomerase-positive circulating epithelial cells in ovarian cancer patients.. Eva Sapi, N I Okpokwasili, T Rutherford

Found on Publication Page
25

Hormonal regulation of the c-fms proto-oncogene in breast cancer cells is mediated by a composite glucocorticoid response element. Maryann B Flick, Eva Sapi, Barry M Kacinski

Found on Publication Page
In 2001
24

The use of the L-plastin promoter for adenoviral-mediated, tumor-specific gene expression in ovarian and bladder cancer cell lines.. X Y Peng, J H Won, T Rutherford, T Fujii, D Zelterman, G Pizzorno, E Sapi, J Leavitt, B Kacinski, R Crystal, P Schwartz, A Deisseroth

Found on Publication Page
23

RU-486 can abolish glucocorticoid-induced increases in CSF-1 receptor expression in primary human breast carcinoma specimens.. B M Kacinski, M B Flick, E Sapi

Found on Publication Page
22

Phospho-fms (p-fms) Expression in Ovarian Sex Cord-stromal Tumors. F. Kommoss, E. Sapi, M. B. Flick, B. M. Kacinski

Found on Publication Page
In 2000
21

Roles of Fas and Fas ligand during mammary gland remodeling.. Joon Song, Eva Sapi, Wendi Brown, Jon Nilsen, Karrie Tartaro, Barry M. Kacinski, Joseph Craft, Frederick Naftolin, Gil Mor

Found on Publication Page
20

Absence of estrogen receptor-beta expression in metastatic ovarian cancer.. T Rutherford, W D Brown, E Sapi, S Aschkenazi, A Muoz, G Mor

Found on Publication Page
19

Absence of estrogen receptor- expression in metastatic ovarian cancer. Thomas Rutherford, Wendi D Brown, Eva Sapi, Sarit Aschkenazi, Amanda Muoz, Gil Mor

Found on Publication Page
In 1999
18

Effect of all-trans-retinoic acid on c-fms proto-oncogene [colony-stimulating factor 1 (CSF-1) receptor] expression and CSF-1-induced invasion and anchorage-independent growth of human breast carcinoma cells.. E Sapi, M B Flick, K Tartaro, S Kim, Y Rakhlin, S Rodov, B M Kacinski

Found on Publication Page
17

Signal transduction pathways regulated by CSF-1 receptors modulate the in vitro radiosensitivity of mammary epithelial cells.. Barry M Kacinski, Sophia Rodov, Eva Sapi

Found on Publication Page
16

The Role of CSF1 in Normal and Neoplastic Breast Physiology. Eva Sapi, Barry M. Kacinski

Found on Publication Page
In 1998
15

Prognostic significance of colony-stimulating factor receptor expression in ipsilateral breast cancer recurrence.. M G Maher, E Sapi, B Turner, A Gumbs, P L Perrotta, D Carter, B M Kacinski, B G Haffty

Found on Publication Page
14

Expression of CSF-I and CSF-I receptor by normal lactating mammary epithelial cells. E Sapi, M B Flick, S Rodov, D Carter, B M Kacinski

Found on Publication Page
13

Ets-2 transdominant mutant abolishes anchorage-independent growth and macrophage colony-stimulating factor-stimulated invasion by BT20 breast carcinoma cells.. E Sapi, M B Flick, S Rodov, B M Kacinski

Found on Publication Page
In 1997
12

Recognition of activated CSF-1 receptor in breast carcinomas by a tyrosine 723 phosphospecific antibody. Maryann B Flick, Eva Sapi, Peter L Perrotta, M Grey Maher, Ruth Halaban, Darryl Carter, Barry M Kacinski

Found on Publication Page
11

Evidence for a role for DNA polymerase beta in mammalian meiosis.. A W Plug, C A Clairmont, E Sapi, T Ashley, J B Sweasy

Found on Publication Page
10

Independent regulation of invasion and anchorage-independent growth by different autophosphorylation sites of the macrophage colony-stimulating factor 1 receptor.. E Sapi, M B Flick, S Rodov, M Gilmore-Hebert, M Kelley, S Rockwell, B M Kacinski

Found on Publication Page
9

25 Specific intracellular signal transduction pathways downstream of CSF1 receptors: Their relationship to breast cancer local recurrence and distant relapse in vivo. Potential targets for the development of new, specific anti-breast cancer therapies to improve local control and block metastatic spread?. Barry M. Kacinski, Eva Sapi, Maryann B. Flick, Bruce Turner, Peter Perrotta, M. Grey Maher, Darryl Carter, Bruce Haffty

Found on Publication Page
In 1995
8

Transcriptional regulation of the c-fms (CSF-1R) proto-oncogene in human breast carcinoma cells by glucocorticoids.. E Sapi, M B Flick, M Gilmore-Hebert, S Rodov, B M Kacinski

Found on Publication Page
In 1994
7

The first intron of human c-fms proto-oncogene contains a processed pseudogene (RPL7P) for ribosomal protein L7.. E Sapi, M B Flick, B M Kacinski

Found on Publication Page
In 1991
6

FMS (CSF-1 receptor) and CSF-1 transcripts and protein are expressed by human breast carcinomas in vivo and in vitro.. B M Kacinski, K A Scata, D Carter, L D Yee, E Sapi, B L King, S K Chambers, M A Jones, M H Pirro, E R Stanley

Found on Publication Page
5

In vitro effect of antitumor drugs on lymphocytic blastogenesis in childhood acute lymphoblastic leukemia (ALL) and non-Hodgkin's lymphoma (NHL).. M Babosa, A Tompa, E Spi

Found on Publication Page
In 1990
4

Correlation between DNA-repair capacity and other cytogenetic endpoints in human lymphocytes measured in low and high cancer risk occupations. A TOMPA, E SAPI, B POOL

Found on Publication Page
3

In vivo and in vitro effect of monochlorinated benzene on human lymphocytes of pesticide workers. E SAPI, A TOMPA, K MARTIN

Found on Publication Page
In 1989
2

[Incidence of somatic mutations of the lymphocytes in subjects working in an environment with cancer risk].. A Tompa, E Spi

Found on Publication Page
1

Detection of 6-thioguanine resistance in human peripheral blood lymphocytes (PBL) of industrial workers and lung cancer patients.. Anna Tompa, Eva Sapi

Found on Publication Page
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