Howard Hendrickson

Sarah J. Phillips, Alison Oliveto, Michael J. Mancino, Howard P. Hendrickson. Development and validation of a rapid liquid chromatography/tandem mass spectrometry method to quantitate gabapentin and buprenorphine in human serum RCM 2021;35(14):e9104.

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Jai Shankar K. Yadlapalli, Zaineb A. F. Albayati, Philip J. Breen, Maxim Dobretsov, Narsimha R. Penthala, Howard P. Hendrickson, Peter A. Crooks. A pharmacokinetic study of morphine-6-O-sulfate in rat plasma and brain. Drug Dev. Res. 2021; https://doi.org/10.1002/ddr.21785

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Xingui Liu, Saikat Poddar , Lin Song, Howard Hendrickson, Xuan Zhang, Yaxia Yuan, Daohong Zhou, Guangrong Zheng, Synthesis and Liver Microsomal Metabolic Stability Studies of a Fluoro-Substituted ----Tocotrienol Derivative, ChemMedChem 2020;15(6):506-516. Doi:10.1002/cmdc.201900676

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Xingui Liu, Zhengya Gao, Qiang Fu, Lin Song, Peiyi Zhang, Xuan Zhang, Howard Hendrickson, Peter A. Crooks, Daohong Zhoua, Guangrong Zheng, Deuteration of the farnesyl terminal methyl groups of ----tocotrienol and its effects on the metabolic stability and ability of inducing G-CSF production, Bioorganic & Medicinal Chemistry 2020;28;115498

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Hambuchen MD, Berquist MD, Simecka CM, McGill MR, Gunnell MG, Hendrickson HP, Owens SM., Effect of Bile Duct Ligation-induced Liver Dysfunction on Methamphetamine Pharmacokinetics and Locomotor Activity in Rats, J Pharm Pharm Sci. 2019;22(1):301-312. doi: 10.18433/jpps30471.

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Liu X, Wang Y, Zhang X, Gao Z, Zhang S, Shi P, Zhang X, Song L, Hendrickson H, Zhou D, Zheng G., Senolytic activity of piperlongumine analogues: Synthesis and biological evaluation. Bioorg Med Chem. 2018;26(14):3925-3938.

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July 1, 2018 - present (5)

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Hambuchen MD, Hendrickson HP, Gunnell MG, McClenahan SJ, Ewing LE, Gibson DM, Berquist MD, Owens SM. The pharmacokinetics of racemic MDPV and its (R) and (S) enantiomers in female and male rats. Drug Alcohol Depend. 2017;179:347-354.

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Hambuchen Michael D, Hendrickson Howard P, Owens S Michael. Chiral determination of 3,4- methylenedioxypyrovalerone enantiomers in rat serum. Analytical Methods. 2017; 9(4):609-617.

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Jai Shankar K. Yadlapalli, Zaineb A. F. Albayati, Narasimha R. Penthala, Howard P. Hendrickson and Peter A. Crooks. Stability studies of potent opioid analgesic, morphine-6-O-sulfate in various buffers and biological matrices by HPLC-DAD analysis. Biomed Chromatogr. 2017; February 15. DOI: 10.1002/bmc.3957.

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Miousse IR, Pathak R, Garg S, Skinner CM, Melnyk S, Pavliv O, Hendrickson H, Landes RD, Lumen A, Tackett AJ, Deutz NEP, Hauer-Jensen M, Koturbash I. Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology. Genes Nutr. 2017;12:22

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M. Christine Arthur, Lin Song, William Culp, Aliza Brown, Michael Borrelli, Robert Skinner, and Howard Hendrickson. Tissue Concentration of Dodecafluoropentane (DDFP) following repeated IV administration in the New Zealand white rabbit. AAPS J. 2017;19(2):520-526. DOI: 10.1208/s12248- 016-0013-0

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Singh VK, Kulkarni S, Fatanmi OO, Wise SY, Newman VL, Romaine PL, Hendrickson H, Gulani J, Ghosh SP, Kumar KS, Hauer-Jensen M. Radioprotective Efficacy of Gamma-Tocotrienol in Nonhuman Primates. Radiat Res. 2016 Mar;185(3):285-98.

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Anita Mitchell, Richard W Hall, Stephen W. Erickson, Charlotte Yates, and Howard Hendrickson. Systemic absorption of cyclopentolate and adverse events after Retinopathy of Prematurity exams. Curr Eye Res. 2016 May 9:1-7.

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Hambuchen MD, Ruedi-Bettschen D, Gunnell MG, Hendrickson H, Owens SM. Chronic treatment of (+)-methamphetamine-induced locomotor effects in rats using one or a combination of two high affinity anti-methamphetamine monoclonal antibodies. Human Vaccines & Immunotherapeutics. 2016;12(9):2240-8.

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Wang J, Shao L, Hendrickson HP, Liu L, Chang J, Luo Y, Seng J, Pouliot M, Authier S, Zhou D, Allaben W, Hauer-Jensen M. Total Body Irradiation in the "Hematopoietic" Dose Range Induces Substantial Intestinal Injury in Non-Human Primates. Radiat Res. 2015 184(5):545-53.

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Gupta PK, Barone G, Gurley BJ, Fifer EK, Hendrickson HP. Hydrastine Pharmacokinetics and Metabolism after a Single Oral Dose of Goldenseal (Hydrastis canadensis) to Humans. Drug Metab Dispos. 2015 Apr;43(4):534-52. PMID: 25609220.

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Hambuchen MD, Carroll FI, Ru---edi-Bettschen D, Hendrickson HP, Hennings LJ, Blough BE, Brieaddy LE, Pidaparthi RR, Owens SM. Combining Active Immunization with Monoclonal Antibody Therapy To Facilitate Early Initiation of a Long-Acting Anti-Methamphetamine Antibody Response. J Med Chem. 2015 Jun 11;58(11):4665-77.

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Gujarathi S, Liu X, Song L, Hendrickson H, Zheng G. A mild and efficient AgSbF6-catalyzed synthesis of fully substituted pyrroles through a sequential propargylation, amination, cycloisomerization reaction. Tetrahedron. 2014 Aug 26;70(34):5267-5273. PMID: 25061238.

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Stack BC Jr, Ye J, Willis R, Hubbard M, Hendrickson HP. Determination of oral bioavailability of fusaric acid in male Sprague-Dawley rats. Drugs R D. 2014 Jun;14(2):139-45 PMID: 24903027.

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Laurenzana EM, Stevens MW, Frank JC, Hambuchen MD, Hendrickson HP, White SJ, Williams DK, Owens SM, Gentry WB. Pharmacological effects of two anti-methamphetamine monoclonal antibodies. Supporting data for lead candidate selection for clinical development. Hum Vaccin Immunother. 2014;10(9):2638-47. PMID: 25483484.

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Madadi NR, Penthala NR, Song L, Hendrickson HP, Crooks PA. Preparation of 4,5 disubstituted- 2H-1,2,3-triazoles from (Z)-2,3-diaryl substituted acrylonitriles. Tetrahedron letters. 2014; 55(30):4207-4211.

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White SJ, Hendrickson HP, Atchley WT, Laurenzana EM, Gentry WB, Williams DK, Owens SM. Treatment with a monoclonal antibody against methamphetamine and amphetamine reduces maternal and fetal rat brain concentrations in late pregnancy. Drug Metab Dispos. 2014 Aug;42(8):1285-91. PMID: 24839971

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Greer AK, Madadi NR, Bratton SM, Eddy SD, Mazerska Z, Hendrickson HP, Crooks PA, Radominska-Pandya A. Novel resveratrol-based substrates for human hepatic, renal, and intestinal UDP-glucuronosyltransferases. Chem Res Toxicol. 2014 Apr 21;27(4):536-45. PMID: 24571610.

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Pathak R, Pawar SA, Fu Q, Gupta PK, Berbe---e M, Garg S, Sridharan V, Wang W, Biju PG, Krager KJ, Boerma M, Ghosh SP, Cheema AK, Hendrickson HP, Aykin-Burns N, Hauer-Jensen M. Characterization of transgenic Gfrp knock-in mice: implications for tetrahydrobiopterin in modulation of normal tissue radiation responses. Antioxid Redox Signal. 2014 Mar 20;20(9):1436-46. PMID: 23521531.

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Crooks PA, Hendrickson HP, Worthen DR, Byrd GD, deBethizy J, et al. Hayes' Principles and Methods of Toxicology. Sixth ed. Hayes A, Kruger CL, editors. Boca Raton, FL: CRC Press; 2014. Chapter 41, Modern Instrumental Methods for Studying Mechanisms of Toxicology; p.1965-2028.

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Gujarathi S, Hendrickson HP, Zheng G. Amberlite IR-120H as an efficient and versatile solid phase catalyst for nucleophilic substitution of propargylic alcohols. Tetrahedron letters. 2013; 54(27):3550- 3553.

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Nanaware-Kharade N, Gonzalez GA 3rd, Lay JO Jr, Hendrickson HP, Peterson EC. Therapeutic anti-methamphetamine antibody fragment-nanoparticle conjugates: synthesis and in vitro characterization. Bioconjug Chem. 2012 Sep 19;23(9):1864-72. PMID: 22873701.

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Quave CL, Este---vez-Carmona M, Compadre CM, Hobby G, Hendrickson H, Beenken KE, Smeltzer MS. Ellagic acid derivatives from Rubus ulmifolius inhibit Staphylococcus aureus biofilm formation and improve response to antibiotics. PLoS One. 2012;7(1):e28737. PMID: 22242149.

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White S, Laurenzana E, Hendrickson H, Gentry WB, Owens SM. Gestation time-dependent pharmacokinetics of intravenous (+)-methamphetamine in rats. Drug Metab Dispos. 2011 Sep;39(9):1718-26. PMID: 21632964.

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Gupta PK, Brown J, Prabath BG, Thaden J, Deutz NE, et al. Development of high-throughput HILIC-MS/MS methodology for plasma citrulline determination in multiple species. Analytical Methods. 2011; 3(8):1759-1768.

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Chimalakonda KC, Hailey C, Black R, Beekman A, Carlisle R, Lowman-Smith E, Singletary H, Owens SM, Hendrickson H. Development and validation of an LC-MS/MS method for determination of phencyclidine in human serum and its application to human drug abuse cases. Anal Methods. 2010 Sep 1;2(9):1249-1254. PMID: 20959870.

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Laurenzana EM, Hendrickson HP, Carpenter D, Peterson EC, Gentry WB, West M, Che Y, Carroll FI, Owens SM. Functional and biological determinants affecting the duration of action and efficacy of anti-(+)-methamphetamine monoclonal antibodies in rats. Vaccine. 2009 Nov 23;27(50):7011-20. doi: 10.1016/j.vaccine.2009.09.072. Epub 2009 Oct 1. PubMed PMID: 19800446; PubMed Central PMCID: PMC2792920. Free full textCited in PMCRelated citations

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White SJ, Laurenzana EM, Gentry WB, Hendrickson HP, Williams DK, Ward KW, Owens SM. Vulnerability to (+)-methamphetamine effects and the relationship to drug disposition in pregnant rats during chronic infusion. Toxicol Sci. 2009 Sep;111(1):27-36. doi: 10.1093/toxsci/kfp127. Epub 2009 Jun 10. PubMed PMID: 19520673; PubMed Central PMCID: PMC2726297. Free full textCited in PMCRelated citations

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Gupta PK, Hubbard M, Gurley B, Hendrickson HP. Validation of a liquid chromatography-tandem mass spectrometric assay for the quantitative determination of hydrastine and berberine in human serum. J Pharm Biomed Anal. 2009 May 1;49(4):1021-6. doi: 10.1016/j.jpba.2009.01.036. Epub 2009 Feb 6. PubMed PMID: 19269122. Cited in PMCRelated citations

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Hendrickson HP, Hardwick WC, McMillan DE, Owens SM. Bioavailability of (+)- methamphetamine in the pigeon following an intramuscular dose. Pharmacol Biochem Behav. 2008 Sep;90(3):382-6. doi: 10.1016/j.pbb.2008.03.012. Epub 2008 Mar 29. PubMed PMID: 18455783;

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Peterson EC, Laurenzana EM, Atchley WT, Hendrickson HP, Owens SM. Development and preclinical testing of a high-affinity single-chain antibody against (+)-methamphetamine. J Pharmacol Exp Ther. 2008 Apr;325(1):124-33. doi: 10.1124/jpet.107.134395. Epub 2008 Jan 11. PubMed PMID: 18192498; PubMed Central PMCID: PMC2773181. Free full textCited in PMCRelated citations

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Naef L, Srivastava L, Gratton A, Hendrickson H, Owens SM, Walker CD. Maternal high fat diet during the perinatal period alters mesocorticolimbic dopamine in the adult rat offspring: reduction in the behavioral responses to repeated amphetamine administration. Psychopharmacology (Berl). 2008 Mar;197(1):83-94. Epub 2007 Nov 16. PubMed PMID: 18004547. Cited in PMCRelated citations

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Hendrickson H, Laurenzana E, Owens SM. Quantitative determination of total methamphetamine and active metabolites in rat tissue by liquid chromatography with tandem mass spectrometric detection. AAPS J. 2006 Nov 22;8(4):E709-17. PubMed PMID: 17233534; PubMed Central PMCID: PMC2751367. Free full textCited in PMCRelated citations

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Milesi-Halle--- A, Hendrickson HP, Laurenzana EM, Gentry WB, Owens SM. Sex- and dose- dependency in the pharmacokinetics and pharmacodynamics of (+)-methamphetamine and its metabolite (+)-amphetamine in rats. Toxicol Appl Pharmacol. 2005 Dec 15;209(3):203-13. PubMed PMID: 15916788. Cited in PMCRelated citations

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Hendrickson HP, Whaley EC, Owens SM. A validated liquid chromatographic/tandem mass spectrometric method for the determination of phencyclidine in microliter samples of rat serum. J Mass Spectrom. 2005 Jan;40(1):19-24. PubMed PMID: 15584009. Cited in PMCRelated citations

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Gentry WB, Ghafoor AU, Wessinger WD, Laurenzana EM, Hendrickson HP, Owens SM. (+)- Methamphetamine-induced spontaneous behavior in rats depends on route of (+)METH administration. Pharmacol Biochem Behav. 2004 Dec;79(4):751-60. PubMed PMID: 15582684. Cited in PMCRelated citations

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Hendrickson HP, Milesi-Halle--- A, Laurenzana EM, Owens SM. Development of a liquid chromatography-tandem mass spectrometric method for the determination of methamphetamine and amphetamine using small volumes of rat serum. J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Jul 5;806(2):81-7. PubMed PMID: 15171915. Cited in PMCRelated citations

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Hendrickson HP, Gurley BJ, Wessinger WD. Determination of dextromethorphan and its metabolites in rat serum by liquid-liquid extraction and liquid chromatography with fluorescence detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 May 25;788(2):261-8. PubMed PMID: 12705966. Related citations

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Muldrew KL, James LP, Coop L, McCullough SS, Hendrickson HP, Hinson JA, Mayeux PR. Determination of acetaminophen-protein adducts in mouse liver and serum and human serum after hepatotoxic doses of acetaminophen using high-performance liquid chromatography with electrochemical detection. Drug Metab Dispos. 2002 Apr;30(4):446-51. PubMed PMID: 11901099. Cited in PMCRelated citations

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DeClue ME, Johnson K, Hendrickson HP, Keck P. Stimulate High School Science Fair Participation by Connecting with a Nearby College. Journal of Chemical Education. 2000; 77(5):608- 609.

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Hendrickson HP, Anderson P, Wang X, Pittman Z, Bobbitt DR. Determination of amino acid composition of peptides using Ru(bpy)33+-chemiluminescent detection and capillary electrophoresis. Microchemical journal, devoted to the application of microtechniques in all branches of science. 2000; 65(2):189-195.

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Hendrickson HP, Anderson P, Wang Y, Pittman Z, Bobbitt DR. Determination of amino acid composition of peptides using Ru(bpy)33+-chemiluminescent detection and capillary electrophoresis. Microchemical journal, devoted to the application of microtechniques in all branches of science. 2000; 65:189-95.

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Bobbitt DR, Jackson WA, Hendrickson HP. Chemiluminescent detection of amines and amino acids using in situ generated Ru(bpy)(3)(3+) following separation by capillary electrophoresis. Talanta. 1998 Aug;46(4):565-72. PubMed PMID: 18967178. Related citations

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Hendrickson HP, Kaufman AD, Lunte CE. Electrochemistry of catechol-containing flavonoids. J Pharm Biomed Anal. 1994 Mar;12(3):325-34. PubMed PMID: 8031931.Cited in PMCRelated citations

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Hendrickson HP, Sahafayen M, Bell MA, Kaufman AD, Hadwiger ME, Lunte CE. Relationship of flavonoid oxidation potential and effect on rat hepatic microsomal metabolism of benzene and phenol. J Pharm Biomed Anal. 1994 Mar;12(3):335-41. PubMed PMID: 8031932.Related citations

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Hendrickson HP, Scott DO, Lunte CE. Identification of 9-hydroxylamine-1,2,3,4- tetrahydroacridine as a hepatic microsomal metabolite of tacrine by high-performance liquid chromatography and electrochemistry. J Chromatogr. 1989 Feb 24;487(2):401-8. PubMed PMID: 2723005.Related citations

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Rapid Communications in Mass Spectrometry (1)

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PubMed Central PMCID: PMC2736803. Free full textCited in PMCRelated citations

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Journal of Pharmaceutical & Biomedical Analysis (26)

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