Research
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List of Publications (91)
In 2023
91

Generation of two induced pluripotent stem cell lines from patients suffering from pulmonary hypertension. G Chen, L Orozco, S Parmisano, JWS Jahng, CD Vera, Y Zhuge, JC Wu, ... Stem Cell Research 72, 103218, 2023.

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90

Dose-Dependent Induction of Nitric Oxide Production in Human Induced Pluripotent Stem Cell-Derived Endothelial Cells by Poloxamer 188. G Chen, IY Chen, Z Li, ML Riess, D Obal Circulation 148 (Suppl_1), A195-A195, 2023.

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89

Detecting and measuring of GPCR signaling-comparison of human induced pluripotent stem cells and immortal cell lines. G Chen, D Obal Frontiers in Endocrinology 14, 1179600, 2023.

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88

Nasopharyngeal Ventilation Compared to Facemask Ventilation: A Prospective, Randomized, Crossover Trial in Two Different Elective Cohorts. R Lenhardt, O Akca, D Obal, J Businger, E Cooke, E Cook Cureus 15 (5), 2023.

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In 2022
87

Elucidating effects of environmental exposure using human induced pluripotent stem cell disease modeling. M Chandy, D Obal, JC Wu EMBO Molecular Medicine 14 (11), e13260, 2022.

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86

Micropatterned organoids enable modeling of the earliest stages of human cardiac vascularization. OJ Abilez, H Yang, L Tian, KD Wilson, EH Lyall, M Shen, R Bhoi, Y Zhuge, ... BioRxiv, 2022.07. 08.499233, 2022.

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85

Integrated multilayer omics reveals the genomic, proteomic, and metabolic influences of histidyl dipeptides on the heart. K Yan, Z Mei, J Zhao, MAI Prodhan, D Obal, K Katragadda, B Doelling, ... Journal of the American Heart Association 11 (13), e023868, 2022.

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In 2021
84

Triomic Approach Reveals the Metabolic, Genomic and Proteomic Influences of the Endogenous Histidyl Dipeptides on Heart. K Yan, Z Mei, J Zhao, D Obal, K Katragadda, D Hoetker, DK Posa, J Shah, ... Circulation 144 (Suppl_1), A11110-A11110, 2021.

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83

Multiomics reveals the genomic, proteomic and metabolic influences of the histidyl dipeptides on heart. K Yan, Z Mei, J Zhao, MAI Prodhan, D Obal, K Katragadda, B Doeling, ... bioRxiv, 2021.08. 10.455864, 2021.

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82

Healthy obese. A Wadhwa, D Obal Oxford Textbook of Anaesthesia for the Obese Patient, 213, 2021.

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In 2020
81

Cardiospecific overexpression of ATPGD1 (carnosine synthase) increases histidine dipeptide levels and prevents myocardial ischemia reperfusion injury. J Zhao, DJ Conklin, Y Guo, X Zhang, D Obal, L Guo, G Jagatheesan, ... Journal of the American Heart Association 9 (12), e015222, 2020.

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80

Induced pluripotent stem cells as a platform to understand patient specific responses to opioids and anaesthetics. D Obal, JC Wu British Journal of Pharmacology 177 (20), 4581-4594, 2020.

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79

Is fresh frozen plasma still necessary for management of acute traumatic coagulopathy?. GR Nordmann, D Obal Current Anesthesiology Reports 10, 297-307, 2020.

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78

A guide to understanding "state-of-the-art" basic research techniques in anesthesiology. D Obal, S Wu, A McKinstry-Wu, VL Tawfik Anesthesia & Analgesia 131 (2), 450-463, 2020.

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77

Perioperative analgesic administration during the 2018 parenteral opioid shortage in the United States-A retrospective analysis. RK Kim, Z Gao, T Hastie, D Obal Journal of clinical anesthesia 66, 109892, 2020.

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76

The obesity paradox: does it exist in the perioperative period?. D Obal, A Wadhwa International anesthesiology clinics 58 (3), 14-20, 2020.

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In 2019
75

TRPA1 channel contributes to myocardial ischemia-reperfusion injury. DJ Conklin, Y Guo, MA Nystoriak, G Jagatheesan, D Obal, PJ Kilfoil, ... American Journal of Physiology-Heart and Circulatory Physiology 316 (4 ..., 2019.

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74

Role of Transient Receptor Potential Ankyrin-1 in Isoflurane-Induced Myocardial Depression in Mice. D Obal, K Katragadda, G Jagatheesan, S Dassanayaka, K Brittian, ... Circulation 140 (Suppl_1), A13670-A13670, 2019.

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73

Studying Cardiovascular Effects of Marijuana on Healthy Individuals Using Human Derived Induced Pluripotent Stem Cells. TT Wei, M Chandy, IY Chen, HT Wo, S Khanamiri, M Nishiga, F Seidl, ... Circulation Research 125 (Suppl_1), A497-A497, 2019.

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In 2018
72

Implication of major adverse postoperative events and myocardial injury on disability and survival: a planned subanalysis of the ENIGMA-II trial. WS Beattie, DN Wijeysundera, MTV Chan, PJ Peyton, K Leslie, MJ Paech, ... Anesthesia & Analgesia 127 (5), 1118-1126, 2018.

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71

Histidyl Dipeptide Carnosine Imparts Cardiac Protection During Ischemia Reperfusion Injury by Sequestering Lipid Peroxidation Products and Buffering Intracellular pH. J Zhao, Y Guo, D Conklin, L Guo, D Obal, D Posa, D Hoetker, A Prodhan, ... Circulation 138 (Suppl_1), A16059-A16059, 2018.

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70

NASO-PHARYNGEAL VENTILATION AS AN ALTERNATIVE TO MASK VENTILATION DURING PRE-OXYGENATION. J Businger, D Obal, O Akca, R Lenhardt ANESTHESIA AND ANALGESIA 126 (4), 14-14, 2018.

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69

Implication of Major Adverse Postoperative Events and Myocardial Injury on Disability and Survival: A Planned Subanalysis of the ENIGMA-II Trial. H McMillan, WS Beattie, DN Wijeysundera, DI Sessler, S Wallace, ... .

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In 2017
68

Exercise-induced changes in glucose metabolism promote physiological cardiac growth. AA Gibb, PN Epstein, S Uchida, Y Zheng, LA McNally, D Obal, ... Circulation 136 (22), 2144-2157, 2017.

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67

Red cell storage duration does not affect outcome after massive blood transfusion in trauma and nontrauma patients: a retrospective analysis of 305 patients. A Bautista, TB Wright, J Meany, SK Kandadai, B Brown, K Khalafalla, ... BioMed Research International 2017, 2017.

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66

Transient Receptor Potential Ankyrin-1 Deficiency in Mice Protected Against Myocardial Ischemia-Reperfusion Injury. DJ Conklin, Y Guo, G Jagatheesan, P Kilfoil, M Nystoriak, D Obal, R Bolli, ... Circulation 136 (suppl_1), A20351-A20351, 2017.

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65

Research Article Red Cell Storage Duration Does Not Affect Outcome after Massive Blood Transfusion in Trauma and Nontrauma Patients: A Retrospective Analysis of 305 Patients. A Bautista, TB Wright, J Meany, SK Kandadai, B Brown, K Khalafalla, ... .

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In 2016
64

Casein Kinase 1 Gene Therapy Facilitates Cardiac Regeneration After Myocardial Infarction in Mice. D Obal, K Katragadda, A Tomlin, M Book, A Bhatnagar, Y Guo, R Bolli, ... Circulation 134 (suppl_1), A18896-A18896, 2016.

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In 2015
63

Genetic Deficiency of Glutathione S-Transferase P Increases Myocardial Sensitivity to Ischemia-Reperfusion Injury. DJ Conklin, Y Guo, G Jagatheesan, PJ Kilfoil, P Haberzettl, BG Hill, ... Circulation research 117 (5), 437-449, 2015.

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In 2014
62

Perioperative doses of ondansetron or dolasetron do not lengthen the QT interval. D Obal, D Yang, DI Sessler Mayo Clinic Proceedings 89 (1), 69-80, 2014.

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61

Cardiomyocyte Specific Conditional Overexpression Of Stromal Cell Derived Factor 1 Facilitates Cardiac Regeneration After Permanent Coronary Artery Ligation In Mice. D Obal, K Brittian, M Book, A Bhatnagar, Y Guo, R Bolli, G Rokosh Circulation Research 115 (suppl_1), A132-A132, 2014.

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60

Myocyte-specific overexpression of stromal cell-derived Factor 1 facilitates cardiac regeneration and improves myocardial function after infarction in mice. DER Obal .

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In 2013
59

Cardiac myocyte-specific transgenic ecSOD targets mitochondria to protect against Ca2+ induced permeability transition. J Luo, D Obal, N Dimova, XL Tang, G Rokosh Frontiers in Physiology 4, 295, 2013.

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In 2012
58

Cardiomyocyte-restricted overexpression of extracellular superoxide dismutase increases nitric oxide bioavailability and reduces infarct size after ischemia/reperfusion. D Obal, S Dai, R Keith, N Dimova, J Kingery, YT Zheng, J Zweier, ... Basic research in cardiology 107, 1-14, 2012.

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In 2011
57

Ultrasound guidance for deep peripheral nerve blocks: a brief review. A Wadhwa, SK Kandadai, S Tongpresert, D Obal, RE Gebhard Anesthesiology research and practice 2011, 2011.

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In 2010
56

The effect of aminophylline on loss of consciousness, bispectral index, propofol requirement, and minimum alveolar concentration of desflurane in volunteers. A Turan, Y Kasuya, R Govinda, D Obal, S Rauch, JE Dalton, O Akc a, ... Anesthesia & Analgesia 110 (2), 449-454, 2010.

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55

Single or multiple guidance methods for peripheral nerve blockade in modern-day practice of regional anesthesia. A Wadhwa, RE Gebhard, D Obal Advances in Anesthesia 28 (1), 187-210, 2010.

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54

Overexpression of Cardiomyocyte-specific Extracellular Superoxide Dismutase Increases Nitric Oxide Bioavailability and Reduces Infarct Size after Ischemia/Reperfusion. D Obal, S Dai, R Keith, N Dimova, JR Kingery, YT Zheng, JL Zweier, ... Circulation 122 (suppl_21), A14950-A14950, 2010.

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In 2008
53

Cardiac myocyte-specific expression of inducible nitric oxide synthase protects against ischemia/reperfusion injury by preventing mitochondrial permeability transition. MB West, G Rokosh, D Obal, M Velayutham, YT Xuan, BG Hill, RJ Keith, ... Circulation 118 (19), 1970-1978, 2008.

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In 2007
52

Effect of Aminophylline on Loss of Consciousness, BIS, and Propofol Requirement in Human Volunteers. Y Kasuya, R Govinda, D Obal, A Turan, D Sessler Anesthesiology 107, A521, 2007.

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In 2006
51

Effect of sevoflurane preconditioning on ischaemia/reperfusion injury in the rat kidney in vivo. D Obal, S Dettwiler, C Favoccia, K Rascher, B Preckel, W Schlack European journal of anaesthesiology 23 (4), 319-326, 2006.

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50

Post-conditioning by a short administration of desflurane reduced renal reperfusion injury after differing of ischaemia times in rats. D Obal, K Rascher, C Favoccia, S Dettwiler, W Schlack BJA: British Journal of Anaesthesia 97 (6), 783-791, 2006.

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49

Effects of halothane, sevoflurane and desflurane on the force-frequency relation in the dog heart in vivo. B Preckel, D Obal, J Mo llenheim, J Hennes, M Heiderhoff, V Tha mer, ... Canadian Journal of Anesthesia 53 (11), 1118, 2006.

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48

Les effets de l'halothane, du se voflurane et du desflurane sur la relation force-fre quence des coeurs de chiens in vivo. B Preckel, D Obal, J Mo llenheim, J Hennes, M Heiderhoff, V Tha mer, ... Canadian Journal of Anesthesia/Journal canadien d'anesthe sie 53, 1118-1125, 2006.

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In 2005
47

The influence of mitochondrial KATP-channels in the cardioprotection of preconditioning and postconditioning by sevoflurane in the rat in vivo. D Obal, S Dettwiler, C Favoccia, H Scharbatke, B Preckel, W Schlack Anesthesia & Analgesia 101 (5), 1252-1260, 2005.

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46

The noble gas xenon induces pharmacological preconditioning in the rat heart in vivo via induction of PKC and p38 MAPK. NC Weber, O Toma, JI Wolter, D Obal, J Mu llenheim, B Preckel, ... British journal of pharmacology 144 (1), 123-132, 2005.

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45

Morphine induces late cardioprotection in rat hearts in vivo: the involvement of opioid receptors and nuclear transcription factor B. J Fra ssdorf, NC Weber, D Obal, O Toma, J Mu llenheim, G Kojda, ... Anesthesia & Analgesia 101 (4), 934-941, 2005.

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44

Role of protein kinase C- (PKC ) in isoflurane-induced cardioprotection. D Obal, NC Weber, K Zacharowski, O Toma, S Dettwiler, JI Wolter, ... British journal of anaesthesia 94 (2), 166-173, 2005.

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43

Coronary artery angioplasty for treatment of peri operative myocardial ischaemia. D Obal, D Kindgen Milles, F Schoebel, W Schlack Anaesthesia 60 (2), 194-197, 2005.

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42

Partial liquid ventilation in acute salt water-induced lung injury. P Schober, D Seidel, R Kalb, D Obal, MA Pakulla, SA Loer European Journal of Anaesthesiology| EJA 22 (7), 536-540, 2005.

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41

Peri-operative myocardial ischaemia-Reply. D Obal, D Kindgen-Milles, F Schoebel, W Schlack ANAESTHESIA 60 (7), 715-716, 2005.

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40

Peri operative myocardial ischaemia. CR Ackroyd, QJW Milner, D Obal, D Kindgen Milles, F Schoebel, ... Anaesthesia 60 (7), 714-716, 2005.

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39

Opioide receptors are mediator of late cardio-protection-involvement of the nuclear transcription factor B. J Fra dorf, NC Weber, O Toma, D Obal, G Kojda, B Preckel, W Schlack Cardio-Visionen 3, 149, 2005.

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38

CARDIOVASCULAR ANESTHESIA-The Influence of Mitochondrial K/ATP-Channels in the Cardioprotection of Preconditioning and Postconditioning by Sevoflurane in the Rat In Vivo. D Obal, S Dettwiler, C Favoccia, H Scharbatke, B Preckel, W Schlack Anesthesia and Analgesia 101 (5), 1252-1260, 2005.

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37

CARDIOVASCULAR ANESTHESIA-Morphine Induces Late Cardioprotection in Rat Hearts In Vivo: The Involvement of Opioid Receptors and Nuclear Transcription Factor kB. J Frassdorf, NC Weber, D Obal, O Toma, J Mullenheim, G Kojda, ... Anesthesia and Analgesia 101 (4), 934-941, 2005.

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In 2004
36

Desflurane preconditioning induces time-dependent activation of protein kinase C epsilon and extracellular signal-regulated kinase 1 and 2 in the rat heart in vivo. O Toma, NC Weber, JI Wolter, D Obal, B Preckel, W Schlack The Journal of the American Society of Anesthesiologists 101 (6), 1372-1380, 2004.

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35

Effect of lidocaine on ischaemic preconditioning in isolated rat heart. H Barthel, D Ebel, J Mu llenheim, D Obal, B Preckel, W Schlack British journal of anaesthesia 93 (5), 698-704, 2004.

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34

Haemodynamic changes during halothane, sevoflurane and desflurane anaesthesia in dogs before and after the induction of severe heart failure. B Preckel, J Mu llenheim, J Hoff, D Obal, M Heiderhoff, V Tha mer, ... European journal of anaesthesiology 21 (10), 797-806, 2004.

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33

Continuous intra-arterial blood gas monitoring in rats. MA Pakulla, D Obal, SA Loer Laboratory animals 38 (2), 133-137, 2004.

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32

Hydrochloric acid-induced lung injury: effects of early partial liquid ventilation on survival rate, gas exchange, and pulmonary neutrophil accumulation. MA Pakulla, D Seidel, D Obal, SA Loer Intensive care medicine 30, 2110-2119, 2004.

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31

Sevoflurane-induced preconditioning did not improve renal function after ischaemia/reperfusion: A-203. D Obal, S Dettwiler, S Ley, B Preckel, W Schlack European Journal of Anaesthesiology| EJA 21, 51, 2004.

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30

Xenon induziert eine pharmakologische Prakonditionierung des Rattenherzens in vivo uber eine Induktion der PKC-epsilon und p38 MAPK. NC Weber, O Toma, JI Wolter, D Obal, W Schlack, B Preckel ANASTHESIOLOGIE UND INTENSIVMEDIZIN 45 (12), 691, 2004.

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29

der 18. Wissenschaftlichen Arbeitstage der DGAI. NC Weber, O Toma, JI Wolter, D Obal, W Schlack, B Preckel .

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28

Die Desfluran-induzierte Prakonditionierung wird uber eine zeitabhangige Aktivierung der PKC-epsilon und ERK-2 vermittelt. O Toma, NC Weber, JI Wolter, D Obal, B Preckel, W Schlack ANASTHESIOLOGIE UND INTENSIVMEDIZIN 45 (12), 693, 2004.

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27

Salzsaure-induzierte Lungenschadigung-Effekte einer fruhen partiellen Flussigkeitsbeatmung auf den Gasaustausch und das Uberleben von Ratten. MA Pakulla, D Obal, D Seidel, SA Loer ANASTHESIOLOGIE UND INTENSIVMEDIZIN 45 (12), 701, 2004.

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In 2003
26

Cardioprotection against reperfusion injury is maximal with only two minutes of sevoflurane administration in rats. D Obal, H Scharbatke, H Barthel, B Preckel, J Mu llenheim, W Schlack Canadian Journal of Anesthesia 50 (9), 940-945, 2003.

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25

La cardioprotection contre les le sions de reperfusion est maximale apre s deux minutes seulement d'administration de se voflurane chez des rats. D Obal, H Scharbatke, H Barthel, B Preckel, J Mu llenheim, W Schlack Canadian Journal of Anesthesia 50, 940-945, 2003.

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24

Partial liquid ventilation in acid-induced lung injury-Effects of immediate and delayed initiation. MA Pakulla, D Obal, D Seidel, SA Loer INTENSIVE CARE MEDICINE 29, S147-S147, 2003.

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23

Effect of Proteine Kinase C Inhibition by Staurosporin on Isoflurane Preconditioning in the Rat Heart In Vivo--Selected for Journal Symposium. D Obal, J Muellenheim, S Dettwiler, W Schlack Anesthesiology 99, A1550, 2003.

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22

Cardiothoracic Anesthesia, Respiration and Airway-Cardioprotection against reperfusion injury is maximal with only two minutes of sevoflurane administration in rats. D Obal, H Scharbatke, H Barthel, B Preckel, J Mullenheim, W Schlack Canadian Journal of Anesthesia-Journal Canadien d'Anesthesie 50 (9), 940-945, 2003.

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In 2002
21

Myocardial protection by preconditioning with sevoflurane is further enhanced by sevoflurane administration during reperfusion. D Obal, J Scharbatke, J Mullenheim Anesthesiology 97, A607, 2002.

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In 2001
20

One MAC of sevoflurane provides protection against reperfusion injury in the rat heart in vivo. D Obal, B Preckel, H Scharbatke, J Mu llenheim, F Ho terkes, V Tha mer, ... British Journal of Anaesthesia 87 (6), 905-911, 2001.

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19

Is the protective effect of sevoflurane against myocardial reperfusion injury concentration dependent?. D Obal, B Preckel, H Scharbatke, V Tha mer, W Schlack European Journal of Anaesthesiology| EJA 18, 46, 2001.

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18

How Do Administration Time and Concentration Affect the Cardioprotection by Sevoflurane Against Reperfusion Injury?. D Obal, J Mu llenheim, B Preckel, V Tha mer, W Schlack Anesthesiology 95, A682, 2001.

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17

Left stellate ganglion block has only small effects on left ventricular function in awake dogs before and after induction of heart failure.(Institut fu r Klinische .... J Mullenheim, B Preckel, D Obal, M Heiderhoff, J Hoff, V Tha mer, ... Pain Practice 1 (2), 201-202, 2001.

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16

Two minutes of sevoflurane administration are enough to protect the heart against reperfusion injury. D Obal, J Mu llenheim, H Scharbatke, V Tha mer, W Schlack European Journal of Anaesthesiology| EJA 18, 46-47, 2001.

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In 2000
15

Left stellate ganglion block has only small effects on left ventricular function in awake dogs before and after induction of heart failure. J Mu llenheim, B Preckel, D Obal, M Heiderhoff, J Hoff, V Tha mer, ... Anesthesia & Analgesia 91 (4), 787-792, 2000.

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14

Influence of the angiotensin II AT1 receptor antagonist irbesartan on ischemia/reperfusion injury in the dog heart. B Preckel, W Schlack, M Gonza lez, D Obal, H Barthel, V Tha mer Basic Research in Cardiology 95, 404-412, 2000.

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13

Verringert saure Reperfusion die Infarktgro sse in vivo?: Studie an narkotisierten Hunden. D Obal Shaker, 2000.

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12

Einfluss einer Stellatumblockade auf die Ventrikelfunktion bei Herzinsuffizienz. D Obal, B Preckel, J Mullenheim, V Thamer, W Schlack ANASTHESIOLOGIE UND INTENSIVMEDIZIN 41 (11), 843-843, 2000.

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11

CARDIOVASCULAR ANESTHESIA-Society of Cardiovascular Anesthesiologists-Left Stellate Ganglion Block Has Only Small Effects on Left Ventricular Function in Awake Dogs Before and .... J Mullenheim, B Preckel, D Obal, M Heiderhoff, J Hoff, V Thamer, ... Anesthesia and Analgesia 91 (4), 787-792, 2000.

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In 1999
10

Effect of volatile anaesthetics on frequency-dependency of myocardial contractility in chronically instrumented dogs. D Obal, M Heideroff, B Preckel, V Thamer, W Schlack BRITISH JOURNAL OF ANAESTHESIA 82, 57-58, 1999.

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9

Effect of a left stellate ganglion block on left ventricular function in chronically instrumented dogs. M Heiderhoff, D Obal, B Preckel, V Thamer, W Schlack BRITISH JOURNAL OF ANAESTHESIA 82, 62-62, 1999.

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In 1998
8

Effects of enflurane, isoflurane, sevoflurane and desflurane on reperfusion injury after regional myocardial ischaemia in the rabbit heart in vivo. B Preckel, W Schlack, T Comfere, D Obal, H Barthel, V Tha mer British journal of anaesthesia 81 (6), 905-912, 1998.

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7

Effect of acidotic blood reperfusion on reperfusion injury after coronary artery occlusion in the dog heart. B Preckel, W Schlack, D Obal, H Barthel, D Ebel, S Grunert, V Tha mer Journal of cardiovascular pharmacology 31 (2), 179-186, 1998.

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6

LABORATORY INVESTIGATIONS-Effects of enflurane, isoflurane, sevoflurane and desflurane on reperfusion injury after regional myocardial ischaemia in the rabbit heart in view. B Preckel, W Schlack, T Comfere, D Obal, H Barthel, V Thamer British Journal of Anaesthesia 81 (6), 905-912, 1998.

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In 1997
5

Halothane reduces reperfusion injury after regional ischaemia in the rabbit heart in vivo. W Schlack, B Preckel, H Barthel, D Obal, V Tha mer British journal of anaesthesia 79 (1), 88-96, 1997.

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4

Inotropic effects of different NO-donors in the dog heart in vivo. B Preckel, G Kojda, W Schlack, H Barthel, D Ebel, D Obal, S Grunert, ... PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 433 (6), O37-O37, 1997.

Found on Publication Page
In 1970
3

conklin D., Prabhu S., Zweier J., Bolli R., Bhatnagar A. cardiac myocyte-specific expression of inducible nitric oxide synthase protects against ischemia/reperfusion injury by .... MB West, G Rokosh, D Obal, M Velayutham, YT Xuan, B Hill, R Keith, ... circulation.-2008.-118.-P 1978, 1970.

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Unspecified
2

Perioperative Administration of Ondansetron or Dolasetron is Not Associated with QTc Prolongation. D Obal, D Yang, DI Sessler .

Found on Publication Page
1

Cardiothoracic Anesthesia, Respiration and Airway. B Preckel, D Obal, J Mu llenheim, J Hennes .

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