Shashi Murthy

Profile Picture of Shashi Murthy
Title
Associate Professor
Department
Chemical Engineering
Institution
Northeastern University

Education

  • B.S. (Chemical Engineering) Johns Hopkins University, 1999
  • Ph.D. (Materials Science and Engineering) Massachusetts Institute of Technology, 2003
  • Postdoctoral Fellowship Harvard Medical School and Massachusetts General Hospital, 2003-2005

Research Interests

Point   Cell Surface Phenomena   Care Diagnostics  

  View all research interests

Biography

The primary focus of our research is the design of microfluidic devices for applications in clinical diagnostics and regenerative medicine. These devices are fabricated using technology originally designed for the semiconductor industry and are capable of handling and manipulating small volumes of fluids (down to tens of microliters) and small numbers of cells. Our expertise is in functionalizing microfluidic channels with a broad range of biomolecules and achieving high-resolution cell separation with these simple and easy-to-use devices.

Homepages

Contact Information

  617.373.4017

Research
Not mentioned yet. (?)
List of Publications (35)
In 2011
35

Design, Validation, and Clinical Application of an Endothelial Progenitor Cell Microfluidic Capture Chip in Patients with Cardiovascular Disease,' G. Hansmann, B.D. Plouffe, A. Hatch, A. von Gise, H. Sallmon, R.T. Zamanian, and S.K. Murthy. Journal of Molecular Medicine (in press; 2011).

Found on Publication Text
34

'Thermomagnetic Determination of Fe3O4 Magnetic Nanoparticle Diameters for Biomedical Applications,' B.D. Plouffe, D.K. Nagesha, R.S. DiPietro, S. Sridhar, D. Heiman, S.K. Murthy, and L.H. Lewis. Journal of Magnetism and Magnetic Materials 2011 (published online).

Found on Publication Text
33

'Computational Design Optimization for Microfluidic Magnetophoresis,' B.D. Plouffe, L.H. Lewis, and S.K. Murthy. Biomicrofluidics 5, 013413 (2011).

Found on Publication Text
32

'Lectin-Mediated Microfluidic Capture and Release of Leukemic Lymphocytes from Whole Blood,' D.A.L. Vickers, M. Hincapie, W.S. Hancock, and S.K. Murthy. Biomedical Microdevices 13, 565-571 (2011).

Found on Publication Text
31

'Microfluidic Pillar Array Sandwich Immunofluorescence Assay for Ocular Diagnostics,' J.V. Green, D. Sun, A. Hafezi-Moghadam, K. Lashkari, and S.K. Murthy. Biomedical Microdevices 13, 573-583 (2011).

Found on Publication Text
30

'Engineered Alginate Hydrogels for Effective Microfluidic Capture and Release of Endothelial Progenitor Cells from Whole Blood,' A. Hatch, G. Hansmann, and S.K. Murthy. Langmuir 27, 4257-4264 (2011).

Found on Publication Text
29

'Molecular Mechanochemistry: Strain-Dependent Enzymatic Cleavage of Human Type I Collagen Monomer,' R.J. Camp, M. Lilies, J. Beale, N. Saedi, B. Flynn, E. Moore, S.K. Murthy, and J.W. Ruberti. Journal of the American Chemical Society 133, 4073-4078 (2011).

Found on Publication Text
In 2010
28

'Receptor Expression Changes as a Basis for Endothelial Cell Identification Using Microfluidic Channels,' D.A.L. Vickers and S.K. Murthy. Lab on a Chip 10, 2380-2386 (2010).

Found on Publication Text
27

'Synergic Effects of Crypt-like Topography and ECM Proteins on Intestinal Cell Behavior in Collagen Based Membranes,' L. Wang, S.K. Murthy, G.A. Barabino, and R.L. Carrier. Biomaterials 31, 7586-7598 (2010).

Found on Publication Text
26

'Biocompatibility Assessment of Insulating Silicone Polymer Coatings Using an In Vitro Glial Scar Assay,' A.K.H. Achyuta, V.S. Polikov, A.J. White, H.G. Pryce Lewis, and S.K. Murthy. Macromolecular Bioscience 10, 872-880 (2010).

Found on Publication Text
25

'Mitigation of Reactive Human Cell Adhesion on Poly(dimethylsiloxane) by Immobilized Trypsin,' A.K.H. Achyuta, K.D. Stephens, H.G. Pryce Lewis, and S.K. Murthy. Langmuir 26, 4160'4167 (2010).

Found on Publication Text
In 2009
24

'Deterministic Lateral Displacement as a Means to Enrich Large Cells for Tissue Engineering,' J.V. Green, M. Radisic, and S.K. Murthy. Analytical Chemistry 81, 9178-9182 (2009).

Found on Publication Text
23

'Influence of Micro-well Biomimetic Topography on Intestinal Epithelial Caco-2 Cell Phenotype,' L. Wang, S.K. Murthy, W.H. Fowle, G.A. Barabino, and R.L. Carrier. Biomaterials 30, 6825-6834 (2009).

Found on Publication Text
22

'Development of Microfluidics as Endothelial Progenitor Cell Capture Technology for Cardiovascular Tissue Engineering and Diagnostic Medicine,' B.D. Plouffe, T. Kniazeva, J.E. Mayer, S.K. Murthy, and V.L. Sales. FASEB Journal 23, 3309-3314 (2009). ** Featured in press release and local TV news media.**

Found on Publication Text
21

'Microfluidic Enrichment of a Target Cell Type from a Heterogenous Suspension by Adhesion-Based Negative Selection,' J.V. Green and S.K. Murthy. Lab on a Chip 9, 2245-2248 (2009).

Found on Publication Text
20

'Controlled Capture and Release of Cardiac Fibroblasts using Peptide-Functionalized Alginate Gels in Microfluidic Channels,' B.D. Plouffe, M.A. Brown, R.K. Iyer, M. Radisic, and S.K. Murthy. Lab on a Chip, 9, 1507-1510 (2009). ** Featured as 'Hot Article' by journal.**

Found on Publication Text
19

'Incorporation of Linear Spacer Molecules in Vapor Deposited Silicone Polymer Thin Films,' A.K.H. Achyuta, A.J. White, H.G. Pryce Lewis, and S.K. Murthy. Macromolecules 42, 1970-1978 (2009).

Found on Publication Text
18

'Functionalization-Induced Improvement in Magnetic Properties of Fe3O4 Nanoparticles for Biomedical Applications,' D.K. Nagesha, B.D. Plouffe, M. Phan, L.H. Lewis, S. Sridhar, and S.K. Murthy. Journal of Applied Physics 105, 07B317 (2009).

Found on Publication Text
17

'Effect of Channel Geometry on Cell Adhesion in Microfluidic Devices,' J.V. Green, T. Kniazeva, M. Abedi, D. Sokhey, M.E. Taslim, and S.K. Murthy. Lab on a Chip 9, 677-685 (2009).

Found on Publication Text
16

'Synergistic Effect of Immobilized Laminin and Nerve Growth Factor on PC12 Neurite Outgrowth,' A.K.H. Achyuta, R. Cieri, K. Unger, and S.K. Murthy. Biotechnology Progress 25, 227-234 (2009).

Found on Publication Text
In 2008
15

'Microfluidic Depletion of Endothelial Cells, Smooth Muscle Cells, and Fibroblasts from Heterogeneous Suspensions,' B.D. Plouffe, M. Radisic, and S.K. Murthy. Lab on a Chip 8, 462 (2008).

Found on Publication Text
In 2007
14

'Nanoparticles in Modern Medicine: State of the Art and Future Challenges,' S.K. Murthy. International Journal of Nanomedicine 2, 129-141 (2007).

Found on Publication Text
13

'Peptide-Mediated Selective Adhesion of Smooth Muscle and Endothelial Cells in Microfluidic Shear Flow,' B.D. Plouffe, D.N. Njoka, J. Harris, J. Liao, N.K. Horick, M. Radisic, and S.K. Murthy. Langmuir 23, 5050 (2007).

Found on Publication Text
In 2006
12

'Size-Based Microfluidic Enrichment of Neonatal Rat Cardiac Cell Populations,' S.K. Murthy, P. Sethu, G. Vunjak-Novakovic, M. Toner, and M. Radisic, Biomedical Microdevices 8, 231 (2006).

Found on Publication Text
11

'Micro- and Nano-technology in Cell Separation,' M. Radisic, R.K. Iyer, and S.K. Murthy. International Journal of Nanomedicine 1, 3 (2006).

Found on Publication Text
In 2005
10

'Enrichment Using Antibody Coated Microfluidic Chambers in Shear Flow: Model Mixtures of Human Lymphocytes,' A. Sin, S.K. Murthy, A. Revzin, R.G. Tompkins, and M. Toner. Biotechnology and Bioengineering 91, 816 (2005).

Found on Publication Text
In 2004
9

'Effect of Flow and Surface Conditions on Human Lymphocyte Isolation Using Microfluidic Chambers,' S.K. Murthy, A. Sin, R.G. Tompkins, and M. Toner. Langmuir 20, 11649 (2004).

Found on Publication Text
8

'Peptide Attachment to Vapor Deposited Polymeric Thin Films,' S.K. Murthy, B.D. Olsen, and K.K. Gleason. Langmuir 20, 4774 (2004).

Found on Publication Text
7

'Vapor Deposition of Biopassivation Coatings for Neuroprostheses.' S.K. Murthy, D.J. Edell, and K.K. Gleason. In Neuroprosthetics: Theory and Practice, K.W. Horch and G. Dhillon, Editors; World Scientific Publishing: Singapore (2004).

Found on Publication Text
6

'Effect of Filament Temperature on the Chemical Vapor Deposition of Fluorocarbon-Organosilicon Copolymers.' S.K. Murthy, B.D. Olsen, and K.K. Gleason. Journal of Applied Polymer Science 91, 2176 (2004).

Found on Publication Text
In 2003
5

'Making Thin Polymeric Materials Including Fabrics Microbicidal and also Water-Repellent,' J. Lin, S.K. Murthy, B.D. Olsen, K.K. Gleason, and A.M. Klibanov. Biotechnology Letters 25, 1661 (2003).

Found on Publication Text
4

'Fluorocarbon Dielectrics via Hot Filament Chemical Vapor Deposition,' K.K.S. Lau, S.K. Murthy, H.G. Pryce Lewis, J.A. Caulfield, and K.K. Gleason. Journal of Fluorine Chemistry 122, 93 (2003).

Found on Publication Text
In 2002
3

'Initiation of Cyclic Vinylmethylsiloxane Polymerization in a Hot-Filament Chemical Vapor Deposition Process,' S.K. Murthy, B.D. Olsen, and K.K. Gleason. Langmuir 18, 6424 (2002).

Found on Publication Text
2

'Fluorocarbon-Organosilicon Copolymer Synthesis by Hot Filament Chemical Vapor Deposition,' S.K. Murthy and K.K. Gleason. Macromolecules 35, 1967 (2002).

Found on Publication Text
Unspecified
1

'Bridging the Divide Between Neuroprosthetic Design, Tissue engineering, and Neurobiology,' J.B. Leach, A.K.H. Achyuta, and S.K. Murthy. Frontiers in Neuroengineering (invited review article; available online).

Found on Publication Text
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