Global Leukodystrophy Initiative Clinical Trials Network

**Our Goals****Collaborate** We aim to create a robust research infrastructure that will allow for the collection and analysis of longitudinal natural history data, development of novel clinical outcome assessments, and identification of surrogate biomarkers – ultimately paving the way for transformative therapeutic trials across the leukodystrophies. In parallel to these approaches, the GLIA-CTN will work closely with a diverse group of stakeholders to promote disease awareness and education, advocate for the adoption of universal newborn screening and early diagnostic programs, and establish clinical guidelines to support the short- and long-term care of individuals living with leukodystrophies. **Our Mission** Our shared research infrastructure supports the collection and analysis of robust clinical data and biological specimen to pave the way for transformative therapeutic trials across the leukodystrophies. The [Global Leukodystrophy Initiative Clinical Trials Network](https://glia-ctn.rarediseasesnetwork.org/home "Learn about the Global Leukodystrophy Initiative Clinical Trials Network") (GLIA-CTN) is part of the [Rare Diseases Clinical Research Network](https://rarediseasesnetwork.org/ "Learn about the Rare Diseases Clinical Research Network. Opens in New Window.") (RDCRN), which is funded by the National Institutes of Health (NIH) and led by the [National Center for Advancing Translational Sciences](https://ncats.nih.gov/ "Learn about the National Center for Advancing Translational Sciences. Opens in New Window.") (NCATS) through its [Division of Rare Diseases Research Innovation](https://ncats.nih.gov/about/divisions-and-offices "Learn about the Division of Rare Diseases Research Innovation (DRDRI). Opens in New Window.") (DRDI). GLIA-CTN is funded under grant number U54NS115052 as a collaboration between NCATS, the [National Institute of Neurological Disorders and Stroke](https://www.ninds.nih.gov/ "Learn about the National Institute of Neurological Disorders and Stroke. Opens in New Window.") (NINDS), and the [*Eunice Kennedy Shriver* National Institute of Child Health and Human Development](https://www.nichd.nih.gov/) (NICHD). This website is hosted by the network’s Data Management and Coordinating Center at Cincinnati Children’s Hospital Medical Center, which is funded by NCATS and NINDS under grant number TR002818. The content of this website is solely the responsibility of the GLIA-CTN administrative coordinating center at Children’s Hospital of Philadelphia and does not necessarily represent the official views of the NIH.