Helping to End Addiction Long-term Initiative

**Overview** The National Institutes of Health (NIH) Helping to End Addiction Long-term® Initiative or NIH HEAL Initiative®, was launched in April 2018 to accelerate scientific solutions to address the [national overdose crisis](https://aspr.hhs.gov/legal/PHE/Pages/Opioids-Renewal-15Dec2025.aspx "(opens in a new window)"), including opioid and stimulant use disorders as well as pain. This NIH-wide Initiative is jointly led by the National Institute on Drug Abuse (NIDA) and the National Institute of Neurological Disorders and Stroke (NINDS). Drug overdoses in the United States began rising in the late 1990s, following increased prescribing of opioid analgesics to address the crisis from untreated chronic pain. Overprescription of these medications along with poorly managed pain, led to a growing problem of opioid use disorder (OUD) and opioid-involved overdose fatalities. Opioid overdoses accelerated after 2010, when people with OUD increasingly turned to heroin as a cheaper alternative to prescription opioids. This was followed by the influx of illicit fentanyl – a very potent synthetic opioid—which continues to drive [overdose fatalities](https://www.cdc.gov/nchs/nvss/vsrr/drug-overdose-data.htm "(opens in a new window)") today, often in combination with cocaine, methamphetamine, and other drugs. HEAL research addresses urgent unmet needs across the lifespan – from infancy to adulthood. It encompasses prevention, treatment, and recovery support approaches for people at risk for or with substance use disorder, as well as prevention and management of pain, with the goal of developing evidence-based strategies capable of providing rapid and lasting solutions to the opioid crisis. **The HEAL Initiative is a Collaborative Effort** NIDA leads HEAL research efforts concerning OUD and opioid and other drug related overdoses, and research at the intersection of pain and OUD. NINDS, in collaboration with the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and the National Center for Complementary and Integrative Health (NCCIH) coordinates HEAL research efforts across NIH Institutes and Centers, including NIDA, to develop safe and effective [pain treatment and prevention strategies](https://www.ninds.nih.gov/current-research/trans-agency-activities/pain-consortium "(opens in a new window)"). Virtually every NIH Institute, Center, and Office (ICO) participates in HEAL, and HEAL collaborations extend across the U.S. Department of Health and Human Services, community organizations, research institutions, and the private sector.